Podophyllotoxin, also known as podofilox, is a non-alkaloid lignan-like toxin. It is extracted from the roots of podophylls. Its ethanol solution and ointment are trade names for gentamicin and verrucile, respectively, and can be used as topical medicine for the treatment of condyloma acuminatum caused by human papillomavirus. Podophyllotoxin and its synthetic derivatives such as etoposide and teniposide show a wide range of options for medical applications such as antiviral and antineoplastic agents. Its anticancer activity has been studied to a large extent and used in the chemotherapy of lung cancer, lymphomas and reproductive tumors.