KimaCell®HPMC K4M hydroxypropyl methyl cellulose is a non-toxic, odorless, white or off-white substance with strong stability to heat, light, and humidity, which is made by etherification of alkali cellulose, propylene oxide, and alkyl chloride. Powder. In the pharmaceutical industry, it is mainly used as a rate-controlling polymer material for coating materials, film materials, and sustained-release preparations. It can also be used as a stabilizer, suspending agent, tablet binder, and viscosity enhancer.

HPMC K4M Viscosity and Molecular Weight

The apparent viscosity of HPMC K4M solutions can be influenced by factors such as concentration, temperature, and shear rate. As a medium-molecular weight hydroxypropyl methylcellulose (HPMC) thickener, HPMC K4M has a viscosity range of 3200.0-4800.0 cps. With a typical molecular weight of approximately 500 kDa (kilodaltons), it provides excellent performance in formulations that demand consistent texture and stability.

Benefits of HPMC K4M 

Exceptional Biocompatibility

Water Solubility and Non-Ionic Nature: HPMC K4M is readily soluble in water and carries no ionic charge, minimizing interactions with drug molecules and ensuring optimal drug stability and bioavailability.

Broad pH Stability: Its stable performance across a wide pH range (2-13) makes it suitable for a variety of pharmaceutical formulations, regardless of the drug's pH sensitivity.

Unique Rheological Properties

Reversible Thermal Gelation: The ability of HPMC K4M to form gels upon heating and return to a liquid state upon cooling is a key feature for controlled release formulations. By carefully adjusting the temperature, precise control over drug release rates can be achieved.