KimaCell®HPMC E50 Hydroxypropylmethylcellulose is a multi-purpose non-ionic cellulose derivative, mainly used as a solid preparation disintegration and binder, because the powder of the HPMC E50 has a large surface area and porosity, it can quickly absorb water and swell, and is used in tablets At the same time, the tablet disintegrates quickly, and its rough structure has a large inlay between the drug and the particles, which can significantly increase the hardness of the tablet without affecting the disintegration, thereby accelerating the dissolution rate of the drug and improving the bioavailability. The dosage of this product is generally about 2-5%. In tablet production, HPMC E50 can be used for internal addition in wet granulation, or it can be added externally or both internally and externally for better effect.

What Is HPMC E50

HPMC E50 (Hydroxypropyl Methylcellulose E50) is a type of cellulose ether, a chemically modified form of cellulose. It is produced by reacting natural cellulose with propylene oxide and methyl chloride, resulting in a white, odorless, and tasteless powder. This water-soluble polymer is characterized by its ability to form thick gels, improve solubility, and provide enhanced stability in various formulations. The "E50" in its name refers to its degree of substitution, which is typically around 50%, indicating the amount of hydroxypropyl and methyl groups introduced to the cellulose structure. Methocel E50 is known for its excellent dispersibility and controlled-release properties when dissolved in water. It is considered non-toxic, biodegradable, and environmentally friendly.