Prolistem® is the third generation of SpermHope® treatment, the new kit has improved formula and stronger effect to increase the success chances for non obstructive azoospermia patients. Prolistem® is the outcome of extensive male fertility research, as well as animal model research. All of this research has led to development of the Prolistem® treatment, which is based on a better understanding of spermatogenesis. Prolistem® is based on a new concept of testicular cells’ behavior that furthers the understanding of sperm production and the mechanisms of hormonal actions.