Thy peroxidase (TPO), also called thyroperoxidase or thyroid peroxidase igg, catalyzes the iodization of thyroglobulin tyrosine during the biosynthesis of T3 and T4.

TPO is an enzyme expressed mainly in the thyroid, where it is secret into the colloid.

The increased TPO level may reflect the promoted thyroid hormone synthesis, which may cause hyperthyroidism.

The detection of TPO helps with diagnosing Hashimoto's disease (HD) and autoimmune hyperthyroidism; Toxic chronic goiter (Graves); Monitoring the effect of immunotherapy; To detect the possibility of familial thyroid disease; Prediction of postpartum thyroid dysfunction in pregnant women.